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Study Length: Published trials have documented a duration of up to 32 weeks for the 2.4 mg dose, while for the 4.5 mg dose, studies lasted up to 26 weeks

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55 MiR-182-5p directly inhibits the expression of FOXO3a, preventing its binding to -catenin, enhancing the interaction between -catenin and TCF4, and then promoting canonical Wnt signalling

10.1186/1471-2431-12-126 Erratum in BMC Pediatr

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Neurodevelopmental disorder-associated SNIP1 mutation E366G reduces binding to P-SF3B1 A homozygous SNIP1 mutation (E366G) found in ~ 35 individuals from the Amish population has been identified as the genetic cause of a neurodevelopmental disorder characterized by hypotonia, craniofacial abnormalities, and seizures (NEDHCS) 47,48