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Researchers use SGLT2-, SGLT1-, URAT1-, and GLUT9-knockout mouse models to investigate the UA-lowering effect of the SGLT2 inhibitor canagliflozin, and show that the mechanism of this effect involved intraluminal glucose transmission and inhibition of the proximal tubule urate transporter URAT1 (Novikov et al., 2019

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FDA approval and status Ozempic is primarily approved for the treatment of type 2 diabetes, cardiovascular risk reduction, and was recently approved in 2025 for preventing worsening kidney disease in patients with chronic kidney disease (CKD) and type 2 diabetes

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