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Interestingly, in the PREvencin con DIeta MEDiterrnea-Plus (Predimed-Plus) trial in overweight or obese individuals with metabolic syndrome, an increase in dietary choline intake over a one-year period was associated with improved measures of cardiovascular health (i.e., lower serum total cholesterol, serum LDL cholesterol, and systolic and diastolic blood pressure levels) (123)

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N Engl J Med 334:574579 Amori RE, Lau J, Pittas AG (2007) Efficacy and safety of incretin therapy in type 2 diabetes: systematic review and meta-analysis

63 COVID-era shortages demonstrated how easily the supply chain fails under demand stress even without the prompting of an adversary, and instead can be strained by fragile just-in-time inventories and opaque global sourcing

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however, FRU dams consumed more calories from monosaccharides during pregnancy and lactation