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Statistical analysis Statistical analysis and graphing were conducted using GraphPad Prism version 8.0.2

The RNA was resuspended in DEPC-treated water and the concentration was measured on a Nanodrop 2000 spectrometer

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To circumvent the need for intracellular bioactivation of AQ or DEAQ by CYPs, the toxic effects of the synthetic chemically reactive metabolites AQ-QI and DEAQ-QI were studied