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This variation is due to genotypic plasticity as revealed through the upregulation of antioxidative enzyme activities and the accumulation of antioxidants

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A meta-analysis showed that selenium levels in the water, soil, cereal, and corn in KBD endemic regions were lower than they were in non-endemic regions, supporting the fact that the level of selenium in tissue is predominantly affected by dietary intake 23

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21 Animal studies have also shown that roflumilast may have the potential to reduce liver inflammation and damage caused by other agents