doi: 10.1155/2022/9985147 8 MerinoJJReyNBFernndez-GarcaR
A systematic review published in eClinicalMedicine analyzed 18 randomized controlled trials involving 3,771 participants and found that discontinuing GLP-1 receptor agonists resulted in an average weight regain of 5.63 kg, along with an HbA1c increase of 0.25%
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Nicotine improves obesity and hepatic steatosis and ER stress in diet-induced obese male rats
Weight Loss While weight loss is often a desired effect of GLP-1 drugs, it can sometimes be excessive or rapid, leading to: Nutritional deficiencies Gallstones Muscle loss Monitoring weight and nutritional intake is important to ensure that weight loss remains within healthy limits
The Journal of Physiology , 591 , 4655-4666