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Pericytes also react to cytokines and triggers the release of proinflammatory molecules, which leads to BBB breakdown in vitro and induces activation of a proinflammatory state of astrocytes, endothelial cells, and microglia, the brains innate immune cell [31]

For people living with obesity, this system is often dysregulated

For example, semaglutide (injectable) and tirzepatide (injectable) have produced substantial mean reductions in high-quality human trials

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The incidence of hypoglycemia is relatively low due to their mechanism of action

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