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Progesterone works as natures own 5-alpha reductase inhibitor (5-ARI)

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It uses a SNAC absorption enhancer and must be taken on an empty stomach with minimal water, 30 minutes before food

Sci Rep 12(1):8908 Chamberlain K, Riyad JM, Weber T (2017) Cardiac gene therapy with adeno-associated virus-based vectors

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Immobilization aids like slings or walking boots might be necessary to minimize movement while safeguarding the treated joint