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As a result, most GLP-1 therapies are delivered through subcutaneous injection, a small needle just under the skin

The FDA issued a safety communication in 2024 noting that compounded semaglutide and tirzepatide products had generated adverse event reports including hospitalizations from dosing errors and contamination [10]

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The tendency toward reduced IL-1 and TNF- levels in the STZR group, compared with the marked elevations observed in the STZ group, with TNF- reduction reaching statistical significance, supports the role of neuroinflammation in diabetes-related cognitive impairment

Behavioral effects: Some patients experience reduced cravings for alcohol, smoking, or even compulsive shopping