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In this two-tier screening approach, BBB-PAMPA was first employed to eliminate compounds with poor passive permeability, followed by MDR1-MDCK I to screen out P-gp efflux transporters' substrates
3.6.1 Background Stroke is a leading cause of adult-onset neuropsychiatric and neurodegenerative disability, with substantial global prevalence and profound long-term consequences (Elendu et al., 2023)
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KLOW bundles the four levers most often pulled together in research
It promotes mitochondrial fatty acid oxidation and performs other biochemical functions, including acetyl buffering, maintaining sufficient coenzyme A concentrations in mitochondria during anaerobic energy production, stimulating the tricarboxylic acid cycle, and stimulating ATP export from mitochondria during sustained muscle exercise
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