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For example, in the study we cited where berberine went up against metformin, 35% of subjects had significant gastrointestinal upset when taking the 1,500 mg/day dose (three capsules worth)

Lyophilized proteins or larger peptides might need buffers to maintain structure, while small peptides often dissolve readily in water

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Ranganath and colleagues also tracked changes in RA medications as a surrogate for disease activity

Another open-label, randomized phase III inferiority study looked at mean A1c reduction in type 2 diabetics not controlled on metformin when treated with semaglutide or tirzepatide and tirzepatide was again found non-inferior (and even superior) in reducing A1c