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Mechanism of oxidative stress in neurodegeneration

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The number of cells and the extracellular matrix of glomeruli is reduced to alleviate kidney fibrosis by HKC and reverse the increase in the markers of oxidative stress, such as malondialdehyde (MDA), 8-hydroxy-2-deoxyguanosine, total superoxide dismutase (SOD), and nicotinamide adenine dinucleotide phosphate oxidase-4 [39]

However, most anticancer drugs are not good substrates for GSTP1, suggesting that the contribution of GSTP1 to drug resistances might not be dependent on its capacity to detoxify chemicals or drugs