After full recovery, correct cannulation was tested by observing water drinking responsiveness after infusion of 1 l human angiotensin II (Sigma-Aldrich, A9525) at a concentration of 24 M in artificial cerebrospinal fluid (distilled water with 125 mM NaCl, 2.5 mM KCl, 2.6 mM NaHCO 3 , 1.25 mM NaH 2 PO 4 2H 2 O, 25 mM d-glucose monohydrate, 1 mM MgCl 2 , 2 mM CaCl 2 )
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Check fasting glucose daily for the first 2 weeks after starting or increasing dose
For example, type 2 diabetes increases FA uptake and oxidation in the heart ( FABP3 , which mediates FA transmembrane trafficking, was downregulated, while CPT1 , which mediates mitochondrial transport and -oxidation, was upregulated
By Administration Route Most GLP-1 receptor agonists are administered by subcutaneous injection because they are peptide-based molecules that would be degraded by digestive enzymes if taken orally
Cellular mechanisms of hypoxic injury in the developing brain