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Signs that you may be ready to increase your dose Your provider will typically consider a dose increase when: You have been on your current dose for at least 4 weeks with no significant side effects Nausea, vomiting, or stomach discomfort from the previous dose increase has resolved Your weight loss has plateaued at the current dose, and you have not yet reached your goal Your blood sugar levels (if you have diabetes) are not yet in your target range Signs you are not ready to increase Your provider will typically delay a dose increase if: You are still experiencing nausea, vomiting, diarrhea, or stomach pain from your current dose You have missed doses recently due to side effects You have experienced any serious adverse event at the current dose that has not fully resolved Do you need to reach 15 mg

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Diabetes Obes Metab 23:20582066 Mosenzon O, Capehorn MS, De Remigis A, Rasmussen S, Weimers P, Rosenstock J (2022) Impact of semaglutide on high-sensitivity C-reactive protein: exploratory patient-level analyses of SUSTAIN and PIONEER randomized clinical trials