In one study with body composition assessed for a subgroup, lean body mass (which includes muscle and bone) accounted for nearly 40% of the weight lost
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Patients who might be considered for GLP-1 therapy (within licensed indications) and who may experience secondary benefits for binge eating behaviours include: Individuals with binge eating disorder and type 2 diabetes , where GLP-1 agonists address the primary diabetes indication whilst potentially helping with eating patterns Those with BED and obesity who meet NHS eligibility criteria for weight management medications (as defined by NICE TA875 for semaglutide or TA664 for liraglutide, which are narrower than the marketing authorisation) Patients who have not responded adequately to psychological interventions such as cognitive behavioural therapy (CBT) and who have concurrent metabolic conditions Those experiencing significant food cravings and loss-of-control eating as part of their weight management challenges However, important cautions and considerations apply
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Cryptic distant relatives are common in both isolated and cosmopolitan genetic samples
481 Notably, ACSL4-driven ferroptosis has been found to activate the pyroptosis pathway, leading to elevated levels of IL-1
