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Chest 158:S72S78

doi: 10.2147/COPD.S306406 101 MillsKHG

The practical considerations for researchers differ from the clinical perspective in important ways

The ingredient list consists of purified water, glutathione, cyclodextrin, ascorbic acid, sodium hydroxide, dexpanthenol, Leuconostoc/radish root extract ferment filtrate, Lonicera japonica flower extract, Lonicera caprifolium flower extract, Populus tremuloides bark extract, potassium sorbate and gluconolactone

Notably, the 1,4-dihydropyridine ring oxidized analogue (KL7) completely lost the adjuvant activity, presumably due to altered electronic structure, reduced conformational flexibility, or lost hydrogen bonding capacity (Extended Data Fig