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Effect of pioglitazone compared with glimepiride on carotid intima-media thickness in type 2 diabetes: a randomized trial

GLP-1 agonists can trigger acute kidney injury in dehydrated states and pose thyroid considerations

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Although most patients with confirmed RA have an abnormal test for RF and/ or ACPA, about 15%20% of cases do not have the elevated levels of RF and ACPA [4]

Adverse reactions and tolerability: Since they are administered via injection and affect gastric emptying (particularly in the case of shorter-acting agents), GLP-1 receptor agonists present some tolerability concerns