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However, numerous hyperpigmented brown macules noted on the lips, mucosal surfaces, and genitalia, should alert the clinician for potential Peutz-Jeghers syndrome (Figure 7-6)

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Chin J Cancer Res

But the warning flags are based on well-established cancer biology: FAK signaling is a known driver of tumor aggressiveness, and VEGF pathways are active in more than half of all solid tumors