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A negative feedback mechanism involving the hypothalamus, pituitary gland, and thyroid gland regulates thyroid hormones secretion as follows: The hypothalamus secretes TRH (thyrotropin-releasing hormone), which stimulates TSH (thyroid-stimulating hormone) release from the pituitary gland

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Reactive Fe 2+ in the labile iron pool is involved in the Fenton reaction, leading to the production of ROS, particularly hydroxyl radicals that contribute to oxidative damage of membrane lipids and ferroptosis [37]