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10.3390/molecules20034225 39 PengY

Grisoni F, Neuhaus CS, Hishinuma M, Gabernet G, Hiss JA, Kotera M, Schneider G (2019) De novo design of anticancer peptides by ensemble artificial neural networks

In addition to disturbances in mitochondrial pyruvate metabolism in diabetes, which contributes to excess hepatic gluconeogenesis, this disorder, as well as insulin resistance, is associated with disruptions in lipid and amino acid metabolic homeostasis

446 Sun et al

2019;181:R211R234

If your medication has a warning not to eat grapefruit while taking it, you shouldnt take berberine with it, either.55 (Note, also, that berberine isnt the only supplement that interacts with cytochrome P450)