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However aggregation is likely to be in part due to either primary nucleation in conditions that favor the Cu 1+ charge state such as hypoxia or acidity, or amorphous non-sheet aggregates induced by Cu 2+ (Jin et al., 2011)

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Maintenance : 26 mg every 12 weeks

Zero time values for each drug candidate were established by first treating the serum with ACN, processing the sample as described above, adding drug, and then performing HPLC analysis