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Receptor binding affinity, receptor residence time, and pharmacokinetic properties all influence real-world outcomes

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A study using inulin-type fructans to treat NAFLD patients for 12 weeks found that, although it increased fecal Bifidobacterium content, it failed to significantly reduce liver fat content or improve metabolic and inflammatory mediators, indicating that without weight loss, prebiotic intervention alone may be insufficient to improve NAFLD

Remember: GLP-1 medications like Ozempic are not meant to be quick fixes

Indeed, GLP-1 mimetics and inhibitors of DPP-4, an enzyme that renders GLP-1 and other proglucagon family members inactive, are now well-established therapeutic agents

A small crossover study (N=28) found that exenatide co-administration reduced levothyroxine Cmax by 16% without significantly changing AUC [13]