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However, their direct role in preventing tumorigenesis resulting from oxidative stress remains uncertain because of the application of carcinogen-induced tumor models and the inevitable carcinogen detoxification by antioxidants (Harris and DeNicola, 2020)

Acetylcholine : In vascular vessels, acetylcholine induces endothelium-dependent dilation via the production of endothelial factors, mainly NO, which then diffuses to the underlying VSMC, in which it induces VSMC relaxation

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