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Even if substrate-specificity is different in the rats small intestine, another factor challenges the hypothesis as PAT1 is dependent on the Na + /H + exchanger (NHE3) to create an H + -gradient for the transport

3.4.3 Brainstem GLP-1R expression and functional boundaries At the brainstem level, GLP-1 receptors (GLP-1Rs) are expressed in multiple neuronal populations within the NTS, including PPG neurons and GABAergic neurons (22)