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To summarise, normally occurring reactive astrogliosis is in the first instance an intrinsic and evolutionary conserved set of diverse astrocyte responses that are aimed at neuroprotection, maintenance of tissue homoeostasis and preservation of nervous tissue integrity

After viral exposure, excess media was removed and replaced with fresh A6 media containing 10 mM BSO or 2 mM cysteine and incubated at 27C for 72 h

PMID: 11382369

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Of note are the following two: The 677CT variant, which leads to one of the most common symptoms: disruption of homocysteine metabolism

They are signals of declining regenerative capacity