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Concurrent Improvement in Both Binge Eating and Depressive Symptoms with Naltrexone/Bupropion Therapy in Overweight or Obese Subjects with Major Depressive Disorder in an Open-Label, Uncontrolled Study A 24-week trial of naltrexone ER/bupropion ER in 25 women with MDD and overweight/obesity found significant improvements in binge eating behavior, with 83% reporting minimal issues by week 24

Treatment of obesity by moderate and severe caloric restriction

It may also interfere with certain supplements like licorice or horsetail

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These medications are expensive [11], are likely to require long-term use, and scaling up provision could place a heavy burden on NHS budgets already strained by the management of chronic conditions and recent structural reorganisations [64]