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Based on the published literature on Nrf2, the rise of Nrf2 protein levels is likely due to impaired degradation of the Nrf2 protein, rather than an induction of its transcription or translation

Many studies have confirmed oxidant-antioxidant imbalance in migraine, including NO, malondialdehyde (MDA), thiobarbituric acid reactive substances, thiol, catalase, superoxide dismutase, and glutathione imbalances (141, 142)

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