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This leads to the degeneration and necrosis of dopaminergic neurons in the midbrain substantia nigra, which significantly reduces dopamine levels in the striatum [136]

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During lipid remodeling, two core enzymesacyl-CoA synthetase long-chain family member 4 (ACSL4) and lysophosphatidylcholine acyltransferase 3 (LPCAT3)drive PUFA-dependent ferroptosis (39)

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Chin Med 21 , 67 (2026)