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Some users alternate between local injection near the elbow and systemic injection into abdominal fat, theorizing this provides both targeted and whole-body healing support

People who follow vegan or vegetarian diets, older adults, individuals with digestive issues (like Crohns or celiac), and those taking certain medications (like metformin or acid reducers) are at higher risk of B12 deficiency

Genetic predisposition is one input among many

Dosages typically range from 250 mg to 1,000 mg per day for oral supplements

This is what we call bioavailabilitythe measure of how much of a substance enters your circulation and is able to have an active effect

Last reviewed: June 1, 2026 Last updated: June 1, 2026 Written by: Jay Hastings, CEO of PlexusDx Jay Hastings is the CEO of PlexusDx, a precision health company focused on genetic testing, blood biomarker insights, and personalized wellness recommendations