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But because the biology of GLP-1 receptor agonism is so fundamentally systemic that no single non-animal model can currently capture its full pharmacological footprint

The mean changes from baseline to Week 26 for fasting serum glucose were -32 mg/dL, -16 mg/dL and -27 mg/dL, and for body weight were -2.3 kg, -0.8 kg and +2.8 kg for BYDUREON, sitagliptin, and pioglitazone, respectively

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clinicians should cut maintenance rates roughly in half and monitor for neurologic symptoms

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