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These data, taken together, suggest that the NF-B pathway is activated in SGNs after peroxynitrite treatment and GPX1 can partially block the nuclear translocation of NF-B/p65 and inhibit the activation of the NF-B signaling

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Progress in neuro-psychopharmacology & biological psychiatry, 11 (2-3), 287-290

Further in human cells, the 5-OP accumulation was also accompanied by an oxidative stress response

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