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Why is weight regain after GLP-1s so problematic People using GLP-1 medications can experience significant muscle loss while they are taking the medication, which can have a long-term detrimental effect on their health

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The investigators reported that LR3-IGF-1 produced enhanced potency in the presence of cell-secreted IGFBPs, with the magnitude of enhancement attributable to the reduced-IGFBP-binding property of the analog rather than to increased intrinsic receptor potency