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The FDA has also cautioned that compounded GLP-1s are not FDA-approved, may have inconsistent dosing and could pose safety risks

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(2016), treatment with GLP-1 analog liraglutide significantly improved histological scores, colon weight/length ratio, and reduced inflammatory cytokines and chemokines such as CCL20, IL-33, and IL-22

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A 2021 study found that individuals on a higher dose of GLP-1 lost an average of 15% (34 lbs) weight loss, with 44% of that weight loss (15 lbs) coming from muscle (Wilding et al, 2021)