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It was also established that besides MSU crystals alone, macrophages engulfing MSU crystals and creating granulomas could further spur the generation of M1 macrophage polarization, intensifying interstitial inflammation and propagating chronic kidney disease (CKD) progression (72)

(4) Andersen NB, Malmlf K, Johansen PB, Andreassen TT, rtoft G, Oxlund H

Autism, mitochondrial disease and significant metabolic disorders require individualized medical evaluation

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Akdis CA (2021) Does the epithelial barrier hypothesis explain the increase in allergy, autoimmunity and other chronic conditions

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