However, CagriSema will likely reach market 6-12 months earlier in mid-2027, leverages the proven semaglutide component, and doesn't cause dysesthesia
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In the single-dose part of the study, adverse events (AEs) occurring in 20% of subjects in any of the combination groups that did not occur in the placebo group were muscle spasms, mouth ulcerations/aphthous ulcers, and urinary tract infection (Table 4)
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Clinically, they promote satiety, reduce caloric intake by 20-30%, and yield 15-20% body weight loss in trials like STEP (semaglutide) and SURMOUNT (tirzepatide)