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Specifically, glycogen phosphorylase, the enzyme mediating glycogenolysis, was significantly decreased in GDI1 deficient astrocytes Glycogen is in the brain predominantly, if not exclusively, expressed in astrocytes

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Treatment exposure of up to 104 weeks with tirzepatide did not increase the risk of a composite outcome of four major adverse cardiovascular events in people with type 2 diabetes across a spectrum of diabetes durations and cardiovascular risk levels

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