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Recent B12 administration: Therapeutic injections for deficiency can temporarily raise levels significantly

An Agilent 1290 Infinity II LC System coupled to a 6490 Triple Quad LC-MS (Agilent Technologies, Santa Clara, CA, USA) was used

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Knockout C57BL/6Jmice lacking RST exhibits a substantial increase in urinary uric acid (approximately two folds), underscoring the involvement of RST in renal uric acid reabsorption

These symptoms typically improve as the body adjusts

Additional effects on nutrient handling, including delayed gastric emptying, sustained satiety and preferential reduction of central adiposity, further support metabolic reequilibration [20, 21]