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Common symptoms during this withdrawal phase are: Nausea, vomiting, and diarrhea Severe cravings for opioids Sweating and chills Flu-like symptoms such as fever, body aches, and fatigue Increased heart rate and blood pressure Mood changes, including depression, anxiety, or hopelessness Last Stage: Gradual Improvement For many people, physical withdrawal symptoms begin to gradually get better after 7-10 days