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Mechanistic investigations in human somatic cell cultures have suggested that Epithalon may: Activate telomerase in vitro Support telomere maintenance and reduce the accumulation of DNA replicationassociated errors Potentially modulate the balance between cellular senescence and replicative capacity in experimental systems In parallel, Epithalon has been examined for its ability to interact with oxidative stress pathways and free radical markers, which may contribute to observed longevity-related effects in certain preclinical models

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However, further research is needed to understand their full potential and all details of their mechanism of action, which will enable to expand the therapeutic indications and to determine their optimal use in clinical practice

1974 Jun;71(6):25059

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