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They may be considered as part of dual or triple therapy when specific criteria are met, including BMI thresholds (35 kg/m or 32.5 kg/m in certain ethnic groups) and when weight loss would benefit other obesity-related comorbidities

Summary: GLP-1 receptor agonists can generally be used safely in patients with Hashimoto's disease when thyroid function is well-controlled with levothyroxine and appropriate monitoring is in place

Approximately 25% of total weight lost on tirzepatide was lean mass (SURMOUNT-1 DXA substudy), and in semaglutide trials, that proportion may reach up to 40% (STEP 1 DXA subset)

Lastly, Ozempic reduces appetite and promotes a feeling of fullness, which is highly effective for enhancing weight loss efforts

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However, the safety and efficacy of these combinations may not be well-documented, raising concerns