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Plant Physiol Biochem 171:4965 Smirnoff N (2000) Ascorbic acid: metabolism and functions of a multi-facetted molecule

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Therefore, depletion of NADPH stores in G6PD-d has the potential to both limit the production of ROS by NOX family enzymes, while simultaneously expediting the accumulation of ROS from non-NADPH-dependent sources, such as the mitochondrial electron transport chain, peroxisomal -oxidation, oxidative protein folding, and other cytoplasmic enzymes (xanthine oxidase, cyclooxygenase, lipoxygenase) 95,96

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doi: 10.1016/j.hrtlng.2016.12.004