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In the pituitary gland, it co-localizes with numerous peptide and non-peptide mediators such as corticotropin-like intermediate peptide (CLIP), adrenocorticotropic hormone (ACTH), melanocyte-stimulating hormone (MSH), thyroid-stimulating hormone (TSH), and melanin-concentrating hormone (MCH)

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Front Cell Dev Biol , 9 , 785138

Orexin deficiency is notably associated with narcolepsy in most mammals, including humans, and these individuals exhibit an abnormal GH secretion profile characterized by elevated GH levels during daylight hours and reduced levels at night [48, 49]

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