319 (Pt 1), 117101
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Compounded peptides handled this way are traceable in both directions: the patient knows what is in the vial, and the pharmacy knows who received it
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The arginine substitution dramatically reduces IGFBP binding affinity by approximately 1,000-fold relative to native IGF-1 while the N-terminal extension contributes to extended circulating stability
Unlike tirzepatide, which activates both GLP-1 and GIP receptors, MariTide is a GIPR antagonist antibody/GLP-1R peptide agonist conjugate which means that it activates GLP-1 receptors while blocking GIP responses