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Amanda Adler, a professor of diabetic medicine and health policy at the University of Oxford who was not involved in the study, told Live Science in an email

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Hyperpigmentation was experienced frequently and exclusively in setmelanotide-treated patients (in 63.0% during the RCT period and 63.5% over the full study period)

LUPKIN: Today on the show, a drug that's changing people's lives is also challenging the traditional way we buy and sell medicine, creating a parallel market of copycats that might be here to stay

Discussion According to this meta-analysis, AOMs resulted in significant weight loss while being used, followed by weight regain after treatment discontinuation