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Native amylin and its short-acting analog pramlintide are pulsatile, meal-associated signals

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In addition to NAD+, the KP generates different metabolites: kynurenine, kynurenic acid, 3OH-kynurenine, quinolinic acid, anthranilic acid and 3OH-anthranilic acid

A system transport present in the inner mitochondrial membrane, that involves dicarboxylate and 2-oxoglutarate anion transporters, allows the passage of negatively charged GSH from the cytosol to the mitochondria

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These compounds are generated by activated microglia the CNSs primary immune cells and astrocytes, as well as by neurovascular units consisting of neurons, pericytes, and endothelial cells (38)