10.1007/s00125-017-4372-6 54 HielS.GianfrancescoM
The combination, often called the Wolverine Peptide Stack, is designed for synergistic effects, where the whole is greater than the sum of its parts
As mentioned above, the cysteine or serine of the catalytic signature is located at the beginning of 1 helix which also contains charged residues involved in the proton transfer reaction
Notably, Sucrosomial B12 was the only formulation to rapidly increase circulatory B12 levels from day 1 (whithin 24 h), consistently exceeding the deficiency-borderline threshold (200300 pg/mL), whereas conventional formulations did not achieve similar efficacy
This suggests that tricarboxylic-acid cycle integrity is not compromised in OA
Best taken on an empty stomach for optimal absorption