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"Smaller players will likely need to demonstrate either superior tolerability, novel indication-specific efficacy, meaningfully different dosing convenience, or combination strategies that address limitations of current agents, particularly muscle loss, rather than simply competing on weight-loss magnitude alone," says Nadolsky

[11] In malignant tumors, complete resection is the only known curative treatment (with a sufficiently wide margin or even amputation to improve prognosis)

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Efficient peripheral blood stem cell mobilization with low-dose G-CSF (50 microg/m2) after salvage chemotherapy for lymphoma