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*Correspondence: Mahmoud Abd-Elkareem, [email protected], [email protected] This article was submitted to Ethnopharmacology, a section of the journal Frontiers in Pharmacology Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

Evidence suggests that calcium accumulation in the mitochondria, accompanied by high oxidative stress, affects its permeability and depletes ATP reserves leading to the necrotic death of the cell or to the release of cytocrome C and apoptosis [14]

Williamson, S

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