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Dr Nic Kormas is a Senior Staff Specialist Endocrinologist and Head of Department for the Endocrinology Service at Concord Hospital

That means it activates two hormone pathways

Summary Vitamin E supplements may reduce the risk of heart disease, but the evidence is conflicting

Subsequent trials (STEP 2 through STEP 8) confirmed these findings across diverse patient populations, highlighting the critical role of maintaining therapeutic doses (1.7 mg and 2.4 mg) to sustain weight loss and prevent weight regain

Some patients benefit from a temporary dose increase to 2.7mg or 3.0mg weekly if tolerated