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In fact, small-scale clinical trials have shown that benefit of replacing dopamine neurons may be questionable, and that the therapy caused severe dyskinesias in some subjects

I., Sasaki, M., Beroukhim, R., Stephanopoulos, G., Ligon, A

Lys105 is a GSH and enzyme activator in the GSSCys assay In a first set of experiments, we analysed the effects of the Lys105 replacements on the steady-state kinetics at variable GSSCys and GSH concentrations

Patients should maintain open communication with their healthcare team regarding tolerability

10.18632/oncotarget.3234 133 KoppulaP.ZhangY.ShiJ.LiW.GanB

doi: 10.1016/j.mehy.2020.110480 176